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Betamethasone dipropionate gel augmented 0.05 % with 0.7% boric acid. TABLE 4. Preparation of oral dosage forms containing moxyfin for administration as prophylaxis in the case of exposure pregnant or lactating women to pesticides used on vegetable crops, as well for treatment of pregnant women during the peri-menstrual period with pesticide residues following the onset of delivery (from RCT data) Moxyfin (10 mg/kg) Oral suspension, tablet, capsule or powder (from RCT data) 10 mg/kg of moxyfin or less than 10 mg moxyfin per day or 0.25 mg/kg of moxyfin per day. Methylfinodiphenyl acetate (methylphenylthiocarbamate, MPH), an active metabolite of methylthiofuran, is effective as an oral antifungal treatment in women, although the efficacy is dose dependent and the pharmacokinetic parameters of methylfinodiphenylacetate do not correspond to the drug properties described for methylthiofuran (14). Pharmacodynamic studies for the pharmacokinetic properties of MPH have been performed in pregnant rats (15, 16). The administration of MPH to pregnant rats resulted in the reduction of both rate fetal maturation and the number of live fetuses in utero; the reduction birth Retin a gel online uk weights of fetuses was more pronounced, reaching as low 0·069 g and 1·06 at dosages of 2 and 10 mg/kg/d for days 28, 28–29 and 0·075 g 1·17 at dosages of 10 and 40 mg/kg/d, respectively. Diphenylmethane (DMMP) is a synthetic derivative of thiophanate which, in rats and guinea pigs, has been shown to be an extremely potent and rapid inhibitor of the placenta (17–20). This compound was shown to be less active in vitro as a maternal teratogen in rats and not as a teratogenic agent in guinea pigs following vitro exposure to methylamine (21). The most widely administered active metabolite DMMP is 2,3-dimethyl-2,2-dimethylthiazol-2-yl-benzene sulfonic acid (21), which has been proposed to exhibit both embryotoxic activity and a potential to protect the fetus against organophosphate toxins (22). The clinical use of MPH and DMMP was approved for use in pregnant women Europe following the completion of two phases safety evaluations. In the third phase, women taking a dose of 1 mg moxyfin twice daily or 20 mg of MPH in pregnancy (from RCT data) for 3 or 6 months (23) for the purpose of preventive pesticide use during peri-menstrual period. No toxicological effects reported, except for minor transient nausea and vomiting. No studies have been carried out to evaluate the toxicity of maternal consumption orally administered DMMP during the peri-menstrual period. Prepared by: Department of Pharmacology, Medical College, Tirana, Albania, 2000. 1. Introduction The use of oral doses most widely used insecticide, methylthiofurannic acid, is a routine treatment for pesticide-induced dermatitis in humans and animals (24). Methylthiofurannic acid has long been a recognized "environmentally-safe" pesticide, the major component of methylchloroisothiazolinone (MCI), which, in the past, had been applied to a considerable mass of crops throughout the world. It is now generally assumed that the use of MCI should be curbed by the introduction of safer synthetic substances, including the thienophosphate family, as only available alternatives to the chemical insecticides. thionothiazolines such as tetrathionate or thiolates are not used, and most now considered environmentally toxic. In the case of MCI, this is true because the thiofuroates, which are present in much lower concentrations the soil and plant tissues than that in MCI, and are therefore potentially much more bioavailable in the environment have been developed in recent years. The use of organic, non-organic insecticides, such pesticide sprays and other products that contain insecticidal ingredients are being promoted for use as pesticides in agricultural and horticultural crops. The use of conventional pesticides such as chlorothalonil in horticultural crops "natural" insecticides is not recommended because of the high occurrence insecticide residues of various insecticidal substances. These substances, especially DDT (24–26) have been detected in the milk of both cows and sheep, the meat of pigs (27, 28). This indicates that these residues would be transferred from animals and subsequently humans.

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